221. Nobles, Jr., D.R. and R.M. Brown, Jr. 2007 Many Paths Up the Mountain: Tracking the Evolution of Cellulose Biosynthesis. In Cellulose: Molecular and Structural Biology. Springer pp 1-15.
Available evidence supports a common ancestry for all cellulose synthases. These enzymes appear to have been a bacterial invention acquired by various eukaryotes via multiple lateral gene transfers. However, the proteins associated with regulation of cellulose biosynthesis and polymer crystallization seem to have evolved independently. Sequence divergence of eukaryotic cellulose synthase and the presence of multiple gene clusters associated with bacterial cellulose synthases are discussed in relation to the possible evolutionary pathways of cellulose biosynthesis.
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