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(A) Computer model of ornithine decarboxylase from the X-ray projection structure (courtesy, M.L. Hackert). The view depicted is along the intramolecular axis. The six dimers that make up the active enzyme aggregate to form a dodecamer with hexagonal symmetry. Also note areas of differential scattering within each dimer. The image has been converted to a color scale (x 5,200,000).
(B) HRTEM structure of ornithine decarboxylase The hexagonal symmetry of the dodecamer is represented, as well as substructural information within each dimer. Differential scattering information near the pyridoxal phosphate binding site is present to some degree in each dimer (arrow 1). Also present are the wing domains (arrow 2). The image has been normalized, scaled, lowpass filtered, enlarged and centered, rotated in 60o increments, and converted to a color scale (x4,800,000).
Credit to Judith Sharp